Scientists in University of Cincinnati produce fat busting proteins in the laboratory

Researchers have found ways to create in the research laboratory a human protein produced in the liver referred to as Apolipoprotein A5 (APOA 5) that plays a crucial role in metabolizing and clearing excess degrees of triglycerides from the blood vessels These researchers are Mark Castleberry, a doctoral student, and Professor Sean Davidson, both in the UC College of Medicine. The findings are available in the American Society for Biochemistry and Molecular Biology’s Journal of Lipid Research online.

Health issues mainly arise due to accumulation triglycerides a big factor that brings about obesity, diabetes, cardiovascular disease and other health issues. This fat has to be metabolised and circulated sooner in order to avoid it getting accumulated in the bloodstream.

This APOA5 protein governs the circulation of triglycerides. The researchers observed higher proportion of APOA5 contributes to faster removal of the triglyceride. The detailed functionality of APOA5 continues to be little known in the scientific community, even so the scientific community agrees its importance. If the scientists could work out how it works they could think of a drug that uses the same mechanism or trigger it to are better.

“Scientists inserted a man's gene progremmed in DNA into bacteria genetically modified to create human proteins. After those proteins were created, they were removed from the bacteria and filtered for use in studies at the lab bench and in mouse models” said Castleberry. He also said that people can quickly make a much greater amount of the protein using bacterial production than if we tried to isolate it from blood in humans.

Researchers carried out this experiment on the mice which were basically fed a large plate of fat and triglycerides. The researchers analyzed their blood after feeding them and observed the level of fat change because they digested the meal. Then the mice were given APOA5 protein. It rapidly cleared the triglycerides that could have accumulated within their blood.

Reference - https://www.uc.edu/news/articles/2020/03/n20898630.html

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